The agr Locus Regulates Virulence and Colonization Genes in Clostridium difficile 027

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The agr Locus Regulates Virulence and Colonization Genes in Clostridium difficile 027

The transcriptional regulator AgrA, a member of the LytTR family of proteins, plays a key role in controlling gene expression in some Gram-positive pathogens, including Staphylococcus aureus and Enterococcus faecalis. AgrA is encoded by the agrACDB global regulatory locus, and orthologues are found within the genome of most Clostridium difficile isolates, including the epidemic lineage 027/BI/N...

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ژورنال

عنوان ژورنال: Journal of Bacteriology

سال: 2013

ISSN: 0021-9193,1098-5530

DOI: 10.1128/jb.00473-13